Analysis and Application Essay Example | Topics and Well Written Essays - 750 words

Analysis and Application - Essay Example In addition, violent gangs take part in theft and robbery of properties of their neighbors (Klein, 2005). Primary questions to the research were inquiring whether youth gang violence is as a result of illegal drugs and small arms, the contribution of the media in the problem, political and social problems to the problem, and the possible measures taken to alleviate the problem. Violent youth gangs have been blamed by the media for the increasing incidences of violence and crime in Central America cities. They have been blamed for all sorts of crime tat take place in the society. In addition, both the media and the government officials have linked the violent groups to terrorist groups such as al Qaeda (Pope, Lovell and Bradl, 2001). Some of the concepts discussed include the definition of â€Å"youth gang† youth gang is defined according to the composition of the gang, members, leaders and the structure of the gang. All these factors must be outlined I order to look at the problem effectively. This research is valid because it discusses the political and social contexts in which these violent youth gangs emerged. Some of the measures proposed in dealing with the issue include arresting the violent youths, removing them out of the streets as well as reducing their number in the overcrowded Central American prisons. Prison overcrowding by the violent youth gangs can lead to challenging situations such as prison riots and a number of deaths (Dvorak, 1995). The voices fro the field’s study also understands the situation of young people. It is discussed that politicization of the gang matter has exaggerated a clear understanding of the crisis as well as the attempts in coming up with suitable solutions. The study recommends that so as to successfully tackle the issue of youth gangs, proper therapy programs must be put in place. There has to be sufficient investments in the avoidance and remedy

System Issues Research Paper Example | Topics and Well Written Essays - 750 words

System Issues - Research Paper Example Likewise, network engineers construct global IP address in to private IP address via sub netting. These private IP addresses are only accessible within the organization and are configured with a unique IP addresses to each node present on the network. Organization named as JKLevering Inc. is having issues with static IP addressing configuration thought out their computer network. However, organization has two options to consider for assigning IP addresses in a corporate wired LAN environment i.e. Dynamic host routing protocol (DHCP) server and static IP addressing. DHCP works in the form of an agent for assigning private IP to the workstations that are logged on the network. Likewise, DHCP is configured on the router, where a network administrator can specify all the parameters related to it. Moreover, static IP address can also be defined by the router, so that a specific device can receive the same IP address every time (Dhcp.2011). Furthermore, all the services associated with DHC P are conducted by a DHCP server (DHCP server.2011). DHCP facilitate organizations to save time by automatically configuring or assigning IP addresses to the Ethernet interface. ... JKLevering Inc. is facing some issues that are caused by static IP addressing. The first issue is related to security. Likewise, if any hacker accomplishes breaking in the system will keep on attacking because he now knew IP address of the workstation. Moreover, organizations allow access of intranet application to employees who work from home. Static IP do not allow employees to access their workstation from home. However, port forwarding enables the option of accessing a private IP address via a global IP address, consequently making network environment more complex and time consuming. Network engineer also find it difficult to embed static IP addresses to every application or server facilitating business operations (Advantages of DHCP, n.d). In order to identify unauthorized threats within the network, a typical DHCP server identifies other DHCP servers on the network. The functionality of a typical DHCP server is to assign an IP address whenever, a client or network node log in t o the network. However, network engineer must define a pool of private IP addresses, as DHCP server will choose any IP from this defined pool. Therefore, whenever a workstation connects to the network, DHCP server provides IP address, subnet Mask, and default gateway. In addition, DHCP server can also provide information related to WINS and DNS, if required (Advantages of DHCP, n.d). DHCP Configuration In order to configure a typical DHCP server, following steps are required: Step 1 Programs ? Administrative Tools ?DHCP Before installing DHCP services in a Windows Server 2008 environment, static IP address is required for the server. As shown in Fig 1.1, all the required options associated with DHCP can be configured in the DHCP console. Figure 1.1 Step 2 The server will

Gays Adopting Children Essay Example for Free

Gays Adopting Children Essay Society is a flexible structure. Only this way it can serve the best way for its members. Democratic process is aimed to increase the rights of its citizens. Nowadays the theme of sexuality becomes an important social issue. Recognition of rights of homosexuals is an important process, which signifies that a lot of people are ready to express freely their sexual preferences and are ready to fight for their rights. Legalization of homosexual marriages and the right of such couples to adopt children is an important and controversial issue of our time. â€Å"Researchers estimate that the total number of children nationwide living with at least one gay parent ranges from six to 14 million† (Gottman, 105). At the present moment many countries legalized the right of lesbian and gay couples to adapt children. Such countries as Andorra, Belgium, Guam, Iceland, the Netherlands, Sweden, South Africa, Spain, the United Kingdom. It is also legal in some separate parts of the Australia, Canada and the United States. In the United States of America 22 states allow lesbian and gay couples to adopt children. The issue is so burning because for homosexual parents adopting becomes the only way to have a child. Even the artificial insemination can not be applied in all cases. First of all this method can be used only for lesbian couples. In addition another spouse form the couple has to adopt a child in order to become his legal parent. For gay couples this method can not be applied. In addition, adopting is a right of each person. That is the reason the question is more important than just an opportunity for homosexual couples to have children. In April 2001 Holland enlarged the definition of marriage and enabled the people of the same sex to get married. Same did Belgium in 2003. The next was Canada. Same sex couples can get married in San Francisco since February 12 of the 2004, because of an action by their mayor. The question of the legislation of homosexual marriages becomes more and more burning and needs a deep survey. There are a lot of reasons against same sex marriages. One of the reasons is that homosexual marriages contradict the tradition. The idea of homosexual marriages threats the very idea of the sanctity of the marriage. The term marriage should refer to a loving relationship between man and woman. The institution of marriage considers the union of two adults of different sex living together. For centuries the marriage was considered just between the people of the opposite sex and by now the marriage of the people of the same sex can be wrong on an evolutionary scale (Coolidge, 1997). People don’t have much faith in the marriage institutions now and the legislation of the heterosexual marriages can weaken this faith. In addition, if the homosexual marriages are legalized to protect the freedom of human why there should be other restrictions for the marriages such as marring the relative or the age of getting married? So called domino effect can cause the demand to cancel all kinds of restrictions on the marriages. If the marriages between the people of the same sex can be accepted like a demonstration of the free will of the individuals, why can’t be accepted the marriage between the brother and the sister or other close relatives? In the case of legalization of homosexual marriages we speak only about the rights of homosexual people. The issue becomes much more complicated when it comes to adopting children. In this case the rights of both, homosexual parents and the rights of adopted children should be considered. Since children are not able to express their own will during the process of adoption, the society must make an important choice deciding on the rights of children. From the other hand it is necessary to mind the right of homosexual couples, who also have their rights and desires. There are many arguments pro and contra adopting children by homosexual couples. Those who stand for giving homosexual couples this right state that all people must have rights to adopt children. If both parents are able to give their child all normal conditions for living, there is no reason to ban homosexual parents to adopt children. Those, who are against this right, state that homosexual couple will not be able to provide normal life conditions for children. In this case the question about â€Å"normality† arises. Social norms are expanded with each year. Homosexual relations, which were considered sinful and even criminal several centuries ago, become a social norm nowadays. This means that the meaning of â€Å"normal† family structure and â€Å"normal† life conditions can also be transformed with the flow of time. Those, who support an idea to give the right of adopting to homosexual couples state that many children wait for adoption and giving this right to homosexual couple would help to improve the situation. In addition specialists, who stand for the legalization of the right of homosexual couples to adopt children state that only small number of children from heterosexual families have normal life conditions. â€Å"Most children in the United States do not live with two married parents. In fact, according to the 2000 census, only 24% homes were composed of a married mother and father with children living at home. † (Green,1978, p. 19) In the case with homosexual family the children will have two parents, even if they are of the same sex. In â€Å"normal† families children often have only one parent. The proponents of legalization of adoption give data, which proves that children, grown up in one-parent and homosexual families, have same level of emotional and social adaptation as children from heterosexual families. This means that homosexuality of parents has little effect on the development of a child. As state specialists, children are more influenced by their relations with their parents and social surrounding than by the sexual orientation of their parents. Even the American Association of Paediatrics agreed with this opinion and supported the legalization of adoption. In addition, if we turn to legal issues, there is no official reasons to ban homosexual couples to adapt children. There is no special amendment in the Constitution, which would deny gay and lesbian couples their rights to adopt children. Most courts, which should make a decision concerning adopting, are be driven by the interests of a child. It is evident that for children having non-traditional family with loving parents is much better than not have any. If sexual orientation of parents has little impact on the living conditions of their children, homosexuality of parents should not be an obstacle for adopting of a child. There are no serious objections, which would prove that gay and lesbian couples will make bad parents. â€Å"Home environments with lesbian and gay parents are as likely to successfully support a childs development as those with heterosexual parents† (Schelberg, Mitnick 2006) Specialists state that here is not connection between sexual orientation and parenting skills. This means that homosexual people can be perfect parents, same as heterosexual people can be bad ones. In addition there is a legal controversy, concerning the right to adoption. Legally, even single parents have right to adopt children. Here arises a kind of controversy since one person can adopt a child but he or she can not do the same thing if he has a spouse of the same sex. Those, who stand against the legalization of homosexual’s right to adopt a child give their arguments in order to support their position. They state that homosexual environment can have an extremely negative effect on child’s development. Some researches (Golombok, Tasker) state that children, raised by homosexual parents, are more likely to adopt same patterns of sexual behaviour. In other words children, raised in homosexual families have more chances to become homosexuals as well. As Golombok and Tasker state: â€Å"by creating a climate of acceptance or rejection of homosexuality within the family, parents may have some impact on their children’s sexual experimentation as heterosexual, lesbian or gay† (Golombok, Tasker, 1993, p. 124). According to their opinion homosexual couples should not be giving a right to adoption. Sexuality is not only personal affair. It’s also social phenomenon society has to deal with. Woodhorse talks about the fortification of gender roles and restrictions to this roles brought to the social culture by transvestites. He believes that cross-dressing and transvestites make a potential danger for the society as it can lead to the displacement of gender categories and gender roles. On a social and cultural level the two groups (male and female) are equally restricted. (Woodhouse,1996, p. 117). The marriage is an institution aiming to create a family first of all and the family presumes giving birth to children. Homosexual marriage create no opportunities for natural reproduction. Modern science gave people opportunities to have children even in the same sex marriage but a number of problems appear. It’s commonly known that men and women are equal creatures and have same rights and obligations but they are not identical and usually presume different models of behavior, models of reactions and thinking. A lot of research made by scientists proves that the child needs both – a mother and a father to become a full personality (Donovan, 2001). There are some things during the upbringing which can be taken only from women’s or only from men’s behavior patters. The children raised in the homosexual families will not have the opportunity to see both –female and male behavioral patters, which can cause serious problems for their future life. In addition the children raised in a homosexual surrounding are more probably to pick up same lifestyle in the future and to copy the model of homosexual relationship. Another problem the children from the homosexual families can and most probably will come across is an attitude of the surrounding. The children can meet a social hostility from the very beginning of their social interaction due to their family background which can make more difficult the social adaptation in the future (Stone 2006). A lot of homosexual couples meet social and religious disapproval but they have chosen their type of behavior themselves and must be responsible for their decisions. The children raised in the homosexual families do not have this choice. Negative attitude of the church to same sex marriages can create additional problems for children. Another problem appears with the children, adopted by gay couples. The patters of family behavior, which are presented in homosexual families, are very different from patterns, peculiar to heterosexual families. This issue is very important since children most probably will adapt the type of relations they see in their family. Homosexual relations usually are thought to be not traditional ones and talking about sexuality in this type of relations is difficult due to the multiple variations of these relations. There are a lot of distinctions between homosexual and heterosexual relationships. Complementary nature of the most heterosexual relations is not so evident in homosexual ones. In most of the homosexual relations there is a division, which is expressed more directly in heterosexual relations. In homosexual relations two people take different roles. Usually, in both, female and male homosexual relationship there are active and passive partners. The roles may change but usually the division to active and passive partner is saved and this relation is usually transmitted to other spheres of life of the couple. Passive partner usually takes female roles in sex and everyday behaviour. An active partner plays the role of the man accordingly. There are derivations in the models of homosexual relations. Tapinc (1992) distinguishes four additional models of homosexual relations. In the first model both males are homosexual. This is one of traditional homosexual models. â€Å"The homosexual mail pair consists of the erastes and the eromenos, ‘lover’ and ‘beloved’; we can infer an active/passive division, but strictly speaking these are not examples of inserter/receptor terminology. (Norton, p. 2002 5) Homosexual male relations are rarely monogamous. Journal of Sex Research made a study of the sexual profiles of 2,583 older homosexuals. â€Å"Research found that only 2. 7 percent claimed to have had sex with one partner only. Research elsewhere indicated that only a few homosexual relationships last longer than two years, with many men reporting hundreds of lifetime partners† (Bozett 1993, p. 112). This way if homosexual parents get an opportunity to adopt children, this most probably will result in the transformation of the role and functions of family. Children, grown up in such untraditional families with untraditional family values, will use this model in their future families. This may result in the increase of the families with untraditional family values. Possible consequences of this phenomenon are very hard to predict. To sum up, there are many reasons for and against adopting children by gay and lesbian couples, There is no one definite opinion concerning this issue. The debates concerning this subject are hold in several spheres, such as religions, social and political ones. A lot of important factors should be considered in order to take a right decision concerning this issue. Adopting concerns the rights of both – children and homosexual couples and decision should the best way serve to the interests of both sides. References 1. Atlanta Journal-Constitution, (2002, Oct 4). NA. Retrieved February 19, 2008, from Database. Gale Power Search. 2 . Bailey, J. M. , Bobrow, D. , Wolfe, M. Mikach, S. (1995), Sexual orientation of adult sons of gay fathers, Developmental Psychology, 31, 124-129; 3. Bozett, F. W. (1987). Children of gay fathers, F. W. Bozett (Ed. ), Gay and Lesbian Parents (pp. 39-57), New York: Praeger; 4. Coolidge, David Orgon, (March 1997). Same-Sex Marriage? Baehr v. Miike and the Meaning of Marriage, South Texas Law Review, 38:1-119 5. Davidson, Arnold (1987) ‘Sex and the emergence of sexuality’, Critical Inquiry, 14 (Autumn), 16-48, reprinted in 6. Stein, Edward (ed. ), Forms of desire (1992, 1990), 89-132. 7. Donovan, (2001,Sept 14). Judge upholds Florida ban on gay adoption. National Catholic Reporter, p. 37, 39. 8. Gay rights. The Advocate, (2002, April 30). p. 18(1). 9. Gottman, J. S. (1991), Children of gay and lesbian parents, F. W. Bozett M. B. Sussman, (Eds. ), Homosexuality and Family Relations (pp. 177-196), New York: Harrington Park Press; 10. Golombok, S. , Spencer, A. , Rutter, M. (1983), Children in lesbian and single-parent households: psychosexual and psychiatric appraisal, Journal of Child Psychology and Psychiatry, 24, 551-572; 11. Green, R. (1978), Sexual identity of 37 children raised by homosexual or transsexual parents, American Journal of Psychiatry, 135, 692-697; Huggins, S. L. 12. Lewin, Tamar (2001, August 31). Court backs Florida ban on adoption by gays. The New York Times, p. A14 13. Stone, Andrea (2006, Feb 21). Drives to ban gay adoption heat up. USA Today, p. 01A. 14. Schelberg, Neal S. and Carrie L. Mitnick, (2004). Same-Sex Marriage: the Evolving Landscape for Employee Benefits,

Cytomegalovirus Overview

Cytomegalovirus Overview 1. unocompromised host Cytomegalovirus is a significant opportunistic pathogen in immuno-compromised patients. Primary infection, reactivation of latent virus, and reinfection are possible and are often clinically silent. The onset of infection is marked by spiking pyrexia, which may resolve in a few days. Its severity is parallel with the level of immunosuppression, and is greatest in bone marrow transplant (BMT) recipients and AIDS patients with low CD4+ T-cell counts. Solid organ transplant recipients, patients receiving immunosuppressive chemotherapy, and subjects with congenital immunodeficiencies may also be symptomatic (Landolfo et al., 2003). Organ transplantation Cytomegalovirus is one of the most important pathogens that infect (SOT) recipients and is associated with increased morbidity and mortality (Beam and Razonable, 2012). Solid organ transplant recipients are particularly susceptible to CMV-related disease due to the immunosuppression necessary to prevent organ rejection. Patients receiving T-cell depleting therapies are at the highest risk The major risk factor for CMV pneumonia is a CMV-seronegative transplant recipient receiving a CMV-seropositive organ. Because of the multiple human strains of CMV, seropositive organ recipients are at risk of re-infection with a different strain of virus. The clinical syndrome is then usually less severe than in primary infection and the onset of disease is often delayed to approximately 6-8 weeks post-transplantation (Alexopouloset al., 2012). Clinical signs of HCMV infection in transplant recipients may be absent or severe, although severe infection is now less frequent as a result of better prophylaxis. HCMV is initially localized in the transplanted organ, but then spreads throughout the gastrointestinal tract and to the retina, skin, endometrium, lungs, and CNS. HCMV disease is more difficult to treat in BMT compared with SOT recipients, and HCMV pneumonia has a high mortality rate, despite the recent introduction of specific antiviral drugs (Landolfo et al., 2003). Lastly, an immunosuppressive syndrome often related to HCMV infection in the late post-transplant period is characterized by superinfection with bacteria, fungi, and protozoa, perhaps due to disturbance of both the humoral and cellular immune response by HCMV (Landolfo et al., 2003). Cytomegalovirus and HIV infection CMV can cause very serious infection in HIV infection (Barrett et al., 2012). Retinitis: Retinitis is the most common manifestation of CMV disease in HIV positive patients. It presents with decreased visual acuity, floaters, and loss of visual fields on one side. It begins as a unilateral disease, but in many cases it progresses to bilateral involvement. It may be accompanied by systemic CMV disease. (Barrett et al., 2012). CMV pneumonia in patients who are HIV positive is uncommon. The reason for this is unknown (Barrett et al., 2012). Gastrointestinal tract: In the upper gastrointestinal tract, CMV has been isolated from oesophageal, gastric and duodenal ulcers. Patients with oesophageal disease may present with painful dysphagia. In the lower gastrointestinal tract, patients with CMV may present with diarrhoea due to colitis (Barrett et al., 2012). CMV may cause disease in the peripheral and central nervous system (Barrett et al., 2012). Replication in the CNS of AIDS patients produces some of the symptoms observed in congenital infection, and is often followed by encephalopathy (Landolfo et al., 2003). Laboratory Diagnosis It is difficult to diagnose CMV infection in immunocompromised patients as it requires not only detection of virus but also determining whether CMV is causing disease. CMV shedding and viremia are common in patients with impaired cellular immunity even when disease due to CMV is not present (Jahan, 2010). Rapid and sensitive technique for diagnosis of CMV infection is of vital importance for the management of immunocompromised patients. A number of rapid and sensitive methods have been developed. These includes DNA probe techniques (Spector and Vacqier, 1983) , Polymerase chain reaction (PCR) (Zipeto et al., 1992), CMV antigen detection in biopsies and bronchoalveolar lavage (Emanuel et al., 1986) and immunofluorescence technique for detection of CMV early antigens in cell (Vander et al., 1988). Moreover, an assay has been developed for CMV antigenemia based on the detection of CMV immediate early antigen (pp65 ) in circulating leucocytes (Boeckh et al., 1996). Histopathology: Histopathology remains the reference standard for diagnosis of tissue-invasive CMV disease (Razonable and Hayden, 2013). CMV infection is indicated by cellular and nuclear enlargement (cytomegalic cells) and the presence of amphophilic to basophilic cytoplasmic inclusions (aggregates of CMV nucleoproteins that are produced during viral replication) (Eid et al., 2010). The severity of CMV infection can be assessed based on the degree of histological involvement (Mattes et al., 2000). While these histopathologic findings are highly characteristic of CMV infection (Mattes et al., 2000), atypical features may be present and may overlap in appearance both with reactive changes and with inclusions of other intracellular viruses. Hence, the diagnosis can be confirmed further by in situ hybridization (ISH) or immunohistochemical (IHC) testing (Razonable and Hayden, 2013). The ISH uses CMV-specific cDNA probes that bind to viral DNA in the cellular materialÂÂ   (Razonable and Hayden, 2013). Likewise, IHC uses monoclonal or polyclonal antibody against early CMV antigen (ChemalyÂÂ   et al., 2004 Histopathology requires an invasive procedure to obtain tissue samples for testing (Eid et al., 2010). As a result, clinicians are often hesitant to perform it. Moreover, repeated biopsies cannot be performed serially to assess the response to treatment (Eid et al., 2010). Accordingly, many clinicians rely on the demonstration of CMV in the peripheral blood by Nucleic acid amplification testing (NAT) or antigen testing to support the clinical diagnosis of tissue-invasive CMV disease in patients with compatible clinical signs and symptoms (Razonable and Humar, 2013). Serology: Serology relies on the sensitive detection of antibodies against CMV in the blood (Vauloup-Fellous et al., 2013). CMV immunoglobulin M (CMV-IgM) is initially secreted during early CMV infection, and the detection of CMV-IgM by serologic assays is indicative of active, acute, or recent infection. Weeks into the course of primary infection, CMV-IgG antibody is secreted, and this antibody persists for life. The detection of CMV-IgG is indicative of previous or past infection (Vauloup-Fellous et al., 2013). Many different assays have been described and evaluated for the detection of CMV IgG antibodies. Among these are complement fixation, ELISA, anticomplement immunofluorescence, radioimmunoassay, and indirect hemagglutination (Ross et al., 2011). Many different assays are available for IgM detection, but enzyme-linked immunosorbent assays (ELISAs) are the most widely used. Recombinant IgM assays using recombinant HCMV proteins and peptides have been developed in an attempt to standardize serological assays. However, studies have shown poor correlation of results obtained with different commercial kits for IgM testing. In addition, assays for IgM antibody lack specificity for primary infection because of false-positive results, because IgM can persist for months after primary infection, and because IgM can be positive in reactivated CMV infections (Ross et al., 2011). Because of the limitations of the IgM assays, IgG avidity assays are utilized in some populations to help distinguish primary from non-primary CMV infection. These assays are based on the observation that IgG antibodies of low avidity are present during the first few months after the onset of infection and avidity increases over time reflecting maturation of the immune response. Thus, high anti-CMV IgG avidity represents longstanding infection in an individual. Avidity levels are reported as the avidity index which is the percentage of IgG bound to the antigen following treatment with denaturing agents (Ross et al., 2011). Seroconversion remains a reliable means of diagnosing primary CMV infection but usually practical only for closely monitored patients such as transplant recipients, for whom pre and post infection sera are readily available (ONeill et al., 1988 and Pass et al., 1983). Culture: This is highly specific for the diagnosis of CMV infection (Razonable and Humar, 2013). Culture can be performed using the conventional plaque assay or the more rapid shell vial centrifugation culture system (Razonable et al., 2002). Isolation of CMV from most clinical samples (other than urine, saliva, and stool) is highly predictive of the diagnosis of CMV disease or the risk of progression from CMV infection into clinical illness (Razonable et al., 2002). In contrast, the use of urine, saliva, and stool samples for CMV culture is of limited clinical utility because viral shedding may be detected in these specimens in CMV-seropositive patients even in the absence of clinical illness (Razonable and Humar, 2013). For CMV-seronegative patients (seen most commonly in pediatric age groups), however, the isolation of CMV in urine (and other samples) may be clinically relevant, since it is suggestive of active primary infection (instead of shedding) (Razonable and Humar, 2013). The major drawbacks to viral culture are its low to modest sensitivity and long turnaround time (Razonable et al., 2002). Accordingly, the clinical use of viral culture is minimal in the contemporary era, when molecular assays are most commonly used in the clinical setting (Razonable et al., 2002). The remaining major clinical use of viral culture is in the diagnosis of CMV infection by use of samples that have not been validated or optimized for molecular testing (Razonable and Humar, 2013). Viral culture may also be required when phenotypic antiviral drug resistance testing is needed, although advances in molecular genotypic assays have emerged for detecting antiviral drug resistance (Hakki and Chou, 2011). Antigen Testing: CMV antigen detection in the blood is the most commonly used phenotypic method for the rapid and sensitive diagnosis of CMV infection (Razonable and Humar, 2013). CMV antigenemia assay uses monoclonal antibodies to detect the CMV pp65 antigen that is expressed in CMV-infected leukocytes during the early phase of the CMV replication process (Razonable et al., 2002). The result of the test is reported as the number of positive cells per total number of cells counted (Razonable and Humar, 2013). Because pp65 is secreted during viral replication, its detection in peripheral blood leukocytes generally signifies active CMV infection. The CMV antigen assay is a rapid and easy test to perform and has a higher sensitivity than that of virus culture (Razonable and Hayden, 2013). It is able to detect CMV infection earlier than virus culture, with some studies reporting the detection of antigenemia an average of 5 to 14 days before the onset of CMV disease (Razonable and Hayden, 2013). Thus, it can be used to detect early CMV replication and to guide the initiation of preemptive therapy (Singh, 2001). In general, the degree of pp65 antigenemia correlates with the risk of subsequent CMV disease. However, there is a lack of consensus as to the threshold of pp65-positive cells that should trigger the initiation of antiviral therapy (Razonable and Hayden, 2013). In some studies, the sensitivity of pp65 antigenemia testing for the diagnosis of CMV infection was comparable to that of CMV NAT by PCR (Garrigue et al., 2006). One of these studies reported a strong correlation between pp65 antigenemia and CMV PCR performed on whole-blood specimens (Garrigue et al., 2006). Other studies, however, have reported a significantly lower sensitivity of antigenemia testing than those of molecular tests (Pang et al., 2009). Moreover, the plasma PCR assay detected CMV infection 12 days earlier than the antigenemia test (Hadaya et al., 2003). The disadvantages of CMV antigenemia testing are its labor-intensive and manual nature. The interpretation of the test is subjective, and there is limited interlaboratory standardization of thresholds of positive cell counts to guide various clinical actions (Razonable et al., 2002). Blood samples being subjected to pp65 antigenemia testing should be processed rapidly (ideally within 6 h) to optimize sensitivity, since test results depend on the life span of leukocytes ex vivo. Delays in the processing of a sample for longer than 24 h may lead to a significant decrease in the number of detectable pp65-positive cells in the blood (Razonable and Hayden, 2013).

Using the Strengths-Based Model for Social Work Practice Essay

Utilizing strengths based perspective with clients enables social workers to focus on the client and family strengths and abilities instead of focusing on the client and family’s problems, bad behaviors and pathologies. The strengths based perspective applies six principles that guide the social worker professional in assisting client’s with the strengths based model; we all have areas of strength, but sometimes it takes an unbiased third party to notice and help others clearly see what they are capable of achieving, even in the midst of their crisis. Every Individual, Group, Family and Community Has Strengths Weick (1992) states â€Å"every person has an inherent power that may be characterized as life force, transformational capacity, life energy, spirituality, regenerative potential, and healing power, which is a potent form of knowledge that can guide personal and social transformation† (p. 24). No matter the crisis or oppression, it needs to be brought to client’s realization that they are strong, resilient and can overcome. They may not be aware of this inner power due to the constant stress and overwhelming sense of impending doom in their lives, but with the help of the strengths perspective, we can assist clients in realizing that they have strengths as well as weaknesses. Clients want to know that they can rely on social workers to provide adequate resources and respect their current situation, no matter how difficult it may be. Clients want to know that we can empathize with their situation and provide support, care and concern for the issues they are going through ; they need to know that we will help them achieve their goals and not give up on them as many may have before in their lives. Saleeby (2013) states â€Å"your cli... ...rk-practice in an urban context: The potential of a capacity-enhancement perspective. New York: Oxford University Press Epstein, M.H. & Sharma, J.M. (1998). Behavioral and emotional rating scale: A strength-based approach to assessment. Texas: Pro-Ed. Kaplan , L. & Girard, J. (1994). Strengthening high risk families. New York: Lexington Books. Kisthardt, W. (1992). A strengths model of case management: The principles and functions of a helping partnership with persons with persistent mental illness. New York: Longman. Saleeby, D. (2013). The strengths perspective in social work practice. New Jersey: Pearson Education Inc. Weick, A. (1992). Building a strengths perspective for social work. New York: Longman. Weick, A., Rapp, C., Sullivan, W.P. and Kisthardt, W. (1989). A strengths perspective for social work practice. Social Work, 34(4), 350-354.

Myrtle Beach vs. New York City Essay -- compare and contrast paper

Myrtle Beach vs. New York City   Ã‚  Ã‚  Ã‚  Ã‚  Picture a beautiful city surrounded by tall skyscrapers soaring into the clouds and the beautiful statue of liberty standing still on the water. You walk down the street passing hundreds of little shops and restaurants, all the while you are taken a back by the breathtaking beauty of the city that you are gazing upon. Now picture laying on the beach at sunset listening to the ocean waves. The air is crisp and the smell of saltwater is bitter sweet. The locations I’m describing are New York City and Myrtle Beach. I have 2500 dollars to take on vacation to one of these destinations and I am comparing and contrasting the two. I will be considering the cost of travel, food, hotel, and also activity and miscellaneous expenses.   Ã‚  Ã‚  Ã‚  Ã‚  Both locations offer a wide variety of fun. Shopping, sightseeing, dance clubs, and scenery are among both places. To get to New York would take about nine and a half hour’s or approximately 554 miles. My car gets about 40 miles to the gallon and gas prices are about $2.30 a gallon. I would have to fill up twice to get to New York City and twice to get back, which would cost about $120.00. If I stayed for three nights and four days, I would need to set aside another $100.00 dollar’s for gas while traveling the city. If I traveled by plane it would cost $201.00 dollars round trip if tickets were purchased on www.orbitz.com.   Ã‚  Ã‚  Ã‚  Ã‚  Hotels in New York City are very costly especially near the holiday’s. After reviewing some hotels that were near Times Square, I chose to go with a three star hotel at the rate of $184.00 a night. For a total of three nights it would cost $552.00 tax included. That cost would include a room with two double beds, television, high speed internet access, a full kitchen, and a great view of Times Square.   Ã‚  Ã‚  Ã‚  Ã‚  There are a wide variety of restaurants in New York City. You can eat cheap at places like Arturo’s Pizzeria, McHales, Hi Life, and Zen Palate just to name a few. On the other hand you don’t want to miss out on the celebrity owned restaurant’s like Fashion Cafà ©, Planet Hollywood, Tribeca Grill, and Nobu. Since I’m going to be staying for three whole days, we’ll just say that I will eat approximately three meals a day which is a total of nine meals. If I ate four of those meals at twenty dollars or less and the other five at seventy or less, I would need approx... ...maining amount of $800.00 will be set aside for miscellaneous expenses such as extra gas money, or emergency situations’ like having a flat tire. My grand total in Myrtle Beach would also be the whole amount of $2500.00. Both, New York and Myrtle Beach are very alike in costs, but the city’s offer completely different experiences.   Ã‚  Ã‚  Ã‚  Ã‚  Based on all the information I have obtained I now must make my decision on which one of these places I want to go. Since there really is not much of a difference in cost I am going to make my decision based upon what these places have to offer. New York offers great scenery that I have never laid my eyes upon. Myrtle Beach has great sightseeing also, but I have seen most of what it has to offer. I also wanted to go see a real Broadway show and they don’t have those in Myrtle. My decision is New York City. I want to take in as much of the city as I can. I want to see where the Trade Towers were and I want to see where they will stand again someday. I want to experience some of the things that the New York people experience on a daily basis, which are crowded streets, a great night life, and the chance of possibly running into someone famous. Myrtle Beach vs. New York City Essay -- compare and contrast paper Myrtle Beach vs. New York City   Ã‚  Ã‚  Ã‚  Ã‚  Picture a beautiful city surrounded by tall skyscrapers soaring into the clouds and the beautiful statue of liberty standing still on the water. You walk down the street passing hundreds of little shops and restaurants, all the while you are taken a back by the breathtaking beauty of the city that you are gazing upon. Now picture laying on the beach at sunset listening to the ocean waves. The air is crisp and the smell of saltwater is bitter sweet. The locations I’m describing are New York City and Myrtle Beach. I have 2500 dollars to take on vacation to one of these destinations and I am comparing and contrasting the two. I will be considering the cost of travel, food, hotel, and also activity and miscellaneous expenses.   Ã‚  Ã‚  Ã‚  Ã‚  Both locations offer a wide variety of fun. Shopping, sightseeing, dance clubs, and scenery are among both places. To get to New York would take about nine and a half hour’s or approximately 554 miles. My car gets about 40 miles to the gallon and gas prices are about $2.30 a gallon. I would have to fill up twice to get to New York City and twice to get back, which would cost about $120.00. If I stayed for three nights and four days, I would need to set aside another $100.00 dollar’s for gas while traveling the city. If I traveled by plane it would cost $201.00 dollars round trip if tickets were purchased on www.orbitz.com.   Ã‚  Ã‚  Ã‚  Ã‚  Hotels in New York City are very costly especially near the holiday’s. After reviewing some hotels that were near Times Square, I chose to go with a three star hotel at the rate of $184.00 a night. For a total of three nights it would cost $552.00 tax included. That cost would include a room with two double beds, television, high speed internet access, a full kitchen, and a great view of Times Square.   Ã‚  Ã‚  Ã‚  Ã‚  There are a wide variety of restaurants in New York City. You can eat cheap at places like Arturo’s Pizzeria, McHales, Hi Life, and Zen Palate just to name a few. On the other hand you don’t want to miss out on the celebrity owned restaurant’s like Fashion Cafà ©, Planet Hollywood, Tribeca Grill, and Nobu. Since I’m going to be staying for three whole days, we’ll just say that I will eat approximately three meals a day which is a total of nine meals. If I ate four of those meals at twenty dollars or less and the other five at seventy or less, I would need approx... ...maining amount of $800.00 will be set aside for miscellaneous expenses such as extra gas money, or emergency situations’ like having a flat tire. My grand total in Myrtle Beach would also be the whole amount of $2500.00. Both, New York and Myrtle Beach are very alike in costs, but the city’s offer completely different experiences.   Ã‚  Ã‚  Ã‚  Ã‚  Based on all the information I have obtained I now must make my decision on which one of these places I want to go. Since there really is not much of a difference in cost I am going to make my decision based upon what these places have to offer. New York offers great scenery that I have never laid my eyes upon. Myrtle Beach has great sightseeing also, but I have seen most of what it has to offer. I also wanted to go see a real Broadway show and they don’t have those in Myrtle. My decision is New York City. I want to take in as much of the city as I can. I want to see where the Trade Towers were and I want to see where they will stand again someday. I want to experience some of the things that the New York people experience on a daily basis, which are crowded streets, a great night life, and the chance of possibly running into someone famous.

How the business deals with legal factors Essay

A legal factor that has a big impact on Tesco’s is protecting employees which, includes the laws about how many hours an employee can work. This amount of hours depends on the employees contract, if they are a full time member of staff then they have to work between 35-45 hours a week but no more, these hours also have to be over reasonably shift, for example having a 8 hour shift a day over 5 days a week. If they are a part time member then they can work any amount of hours a week as long as it is no longer the 35 hours. This can impact on Tesco’s as they have to keep to the terms and conditions of their contracts with staff , which could affect activates Tesco’s wish to do as they may not fit in the with hours the members of staff involved can work. Tesco’s can deal with this by offering willing to work staff overtime shifts, if staff are willing to do this, it means that Tesco’s doesn’t need to employ any more member which works out better for them as if they were to do this, they would then have to find the correct amount of hours agreed in the contact which might not be available. Even though some staff maybe willing to work more hours, they may feel that because they are helping out the business that they don’t need to be as professional and honest as they are when working their own scheduled shifts, this article (http://www.independent.co.uk/news/business/news/tesco-accused-of-using-electronic-armbands-to-monitor-its-staff-8493952.html)is about how Tesco’s is trying to deal with this issue. Tesco’s has come up with this idea of its warehouse and forklift staff wearing electronic bracelets which helps improve the efficiency of it workers as it means they don’t have to carry around items such as pen and paper as the armband collects this data which also means they are collection correct data. This armband also allows Tesco’s to monitor their staff to check that they are doing their jobs when expected of them and that they are not taking any un-agreed breaks, the arm band also informs the staff of when they are allowed there b reaks. This helps Tesco’s make sure their staff are not working over the hours allowed or working under the hours agreed. A legal factor that impacts Tata motors  is the protection of customers and employees, like all businesses Tata has to keep to legal factors and laws, the need to treat all of their customers fairly and honestly, this helps customers feel they can trust the business as well as giving the a good reputation. Challenges that Tata face when selling their products are making sure they pass the sales of good act which means they need to describe the product exactly how it is and not say it does something it actually doesn’t. It also needs to pass the customer credit act. http://www.business-standard.com/article/pti-stories/tata-motors-focus-on-customer-satisfaction-to-woo-back-buyers-114111600186_1.html this article explains how they are going out of their way to make sure the give there customers the best service they possibly can. The article states that Tata motor has previously had problems with their customer service. They have taken this feedback and actually work on making it better by improving the quality of manufacture and repairs. How the business deal with social factors A common social factor that affects business is equal rights for both man and female workers and peoples religion. This could impact Tesco’s as if anyone feels as though they are being judged or unable to do something because of these reasons then they could cause problems for Tesco’s by making complaints either to their managers or their union. To make sure this doesn’t happen Tesco’s has to make sure that their staff know that everyone treated the same and if there are people applying for a job they cannot turn them away because of these reason, the only way they can do this is if someone is disabled in some way and their disability would stop them from doing the job required, however if this is the care they have to inform this person that is the reason but in a kind way as not to offend them. Tesco’s deal with these possible problem by getting new applicants to have a cv which is what they are judged upon or the job, they then have interview/trial which is so that they are then judged upon their abilities to do the job not on the gender or religious view. Tesco’s has coped well with this issues as if you are to go into their stores you are clearly able to see a balanced level of both male and female staff, Tesco’s also considers the religious view and has there store open later and close early on a Sunday as most religions see this a day of rest.